Experience

Education

Research Experience

Postdoctoral Associate, University of Pittsburgh (Jan 2020 - present)

  • Major research topics: development of a cutting-edge radiofrequency coils for high-resolution human MRI, image processing and disease classification, volumetric analysis of MRI images as biomarkers for neurodegenerative diseases
  • Design, simulation, optimization, CAD modeling and implementation of a 56-channel transmit coil for 7T MRI: this is a major complex project which involves electrical, mechanical, and RF engineering developments and aims to develop an RF head coil with unprecedent performance at 7T.
  • Pre-processing, post-processing, and quantification of MRI images: development of pipelines for hippocampal subfields segmentation, diffusion MRI processing, QSM, fMRI, image denoising, bias correction, distortion correction, parcellation.
  • Support for in-vivo MRI studies: optimization of MRI sequences and procedures, definition of the MR sequences required for patient studies, taking into account the characteristics of each study.

Graduate Student Researcher, University of Pittsburgh (Aug 2014 - Dec 2019)

  • Dissertation entitled "Advances in radiofrequency coil developments for 7 Tesla human MRI"
  • Developed and simulated innovative designs of radio-frequency (RF) antennas for 7 Tesla (7T) MRI using an in-house developed/maintained finite-difference time-domain (FDTD) software.
  • Validated simulations by conducting temperature tests to determine the safe power limits when using the MRI antennas in humans.
  • Developed a MATLAB software for nonlinear optimization of multi-channel RF antenna arrays' excitation ports to achieve maximum homogeneity and efficiency of the magnetic field produced and to reduce the levels of power deposition in the tissues.
  • Implemented and managed the implementation of several RF antenna designs for imaging different parts of the body, including head, body, arm/hand, knee, foot, and breast.
  • Conducted several clinical studies at the University of Pittsburgh, including late-life diseases, schizophrenia, sickle cells disease, small vessels disease, multiple sclerosis, and depression (total more than 500 patients).
  • Developed an innovative image filtering technique and pipelines for diffusion tensor image (DTI), functional MRI, and structural MRI post-processing.
  • Acquired images and optimized protocols for ex-vivo animal and human scans at 7T MRI.

Graduate Student Researcher, University of Sao Paulo (Jul 2012 - Jul 2014)

  • Thesis entitled "Application analysis and design of active circulators for continuous-wave Doppler ultrasound systems."
  • Designed a load-insensitive high-bandwidth active circulator for continuous-wave Doppler ultrasound.
  • Contributed to the upgrade of the CERN Large Hadron Collider, developing alternatives for the current hardware.
  • Developed hardware/software/firmware and graphical interface for acquisition of electrical signals from neurons of small insects.

Undergraduate Student Researcher, University of Sao Paulo (Feb 2006 - Dec 2010)

  • Project entitled "Pulse oximeter with USB communication."
  • Developed from scratch of a pulse oximeter device, including hardware (printed circuit board design, electronics soldering, and microcontroller programming), firmware (Microchip PIC32 microcontroller, programmed using C language), and user interface (LabVIEW).

Industry Experience

Research and Development Engineer, i-Healthsys Medical Products (Jan 2011 - Jul 2014)

  • Development of hardware, firmware, and software for medical and veterinary devices; mechanical prototyping; project management; coordination of staff development; grant writing; search for suppliers and investors
  • Developed a high-resolution, low-noise, and electrically isolated electrocardiograph (ECG), including the hardware, firmware, and graphical interface.
  • Developed a radial tonometer with sphygmomanometer calibration option. This equipment is able to noninvasively measure blood pressure in real time (beat-to-beat).
  • Integrated the ECG, tonometer, sphygmomanometer, and pulse oximeter devices, with a stand-alone computer and graphical interface, resulting in the tilt-table test equipment. This equipment has passed in the clinical trials and is in the certification phase.
  • Developed and tested an optical milk flow meter.
  • Developed a hand hygiene monitor, currently patent-protected and commercially available, that uses radio-frequency (RF) signals to detect the presence of a health care professional in the hospital ward and evaluate if one has performed the hand hygiene before approaching the patient.
  • Developed a remote monitoring system to acquire physiological signals from patients - such as ECG, pulse oximetry, blood pressure, and temperature - and send the information remotely to a health care center. It is also able to give instructions to the patients or caregiver, such as medication schedules
  • Designed hardware for medical and veterinary devices; data acquisition, real-time processing, and presentation using MATLAB and LabVIEW; microcontroller programming using C and Assembly languages.

Electrical Engineering Intern, I-Healthsys Medical Products (Jan 2010 - Dec 2010)

  • Pulse oximeter hardware development
  • Analog filtering development for electrocardiography (ECG)
  • Simple graphical interface for ECG using MATLAB/LabVIEW
  • ECG simulator

Publications

  1. Lucy Liang, Isabela Zimmermann Rollin, Aydin Alikaya, Jonathan C Ho, Tales Santini, Andreea C Bostan, Helen N Schwerdt, William R Stauffer, Tamer S Ibrahim, Elvira Pirondini, David J Schaeffer. An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys . Journal of Neuroscience Methods, 2024
  2. Tiago Martins, Bruno De Almeida, Minjie Wu, Kristine A Wilckens, Davneet Minhas, James W Ibinson, Howard J Aizenstein, Tales Santini, Tamer S Ibrahim. Characterization of pulsations in the brain and cerebrospinal fluid using ultra-high field magnetic resonance imaging . Front. Neurosci., 2024
  3. Tales Santini, Chenyi Chen, Wen Zhu, Jr-Jiun Liou, Elizabeth Walker, Shruthi Venkatesh, Nadim Farhat, Andrea Sajewski, Salem Alkhateeb, Manojkumar Saranathan, Zongqi Xia, Tamer S. Ibrahim Hippocampal subfields and thalamic nuclei associations with clinical outcomes in multiple sclerosis: an ultrahigh field MRI study. Multiple Sclerosis and Related Disorders, 2024
  4. Brandon M. Sibbach, Helmet T. Karim, Daniel Lo, Nithya Kasibhatla, Tales Santini, Jessica C. Weber, Tamer S. Ibrahim, Layla Banihashemi Manual segmentation of the paraventricular nucleus of the hypothalamus and the dorsal and ventral bed nucleus of stria terminalis using multimodal 7 Tesla structural MRI: probabilistic atlases for a stress-control triad. Brain Structure and Function, 2023
  5. Bridget N McGuigan*, Tales Santini*, Matcheri S Keshavan, Konasale M Prasad. Gene expressions preferentially influence cortical thickness of Human Connectome Project Atlas parcellated regions in first-episode antipsychotic-naïve psychoses. Schizophrenia Bulletin Open, 2023. *equal contribuition
  6. S. Aja-Fernández, C. Martín-Martín, A. Planchuelo-Gómez, A. Faiyaz, M.N. Uddin, G. Schifitto, A. Tiwari, S.J. Shigwan, R. Kumar Singh, T. Zheng, Z. Cao, D. Wu, S.B. Blumberg, S. Sen, T. Goodwin-Allcock, P.J. Slator, M. Yigit Avci, Z. Li, B. Bilgic, Q. Tian, X. Wang, Z. Tang, M. Cabezas, A. Rauland, D. Merhof, R. Manzano Maria, V.P. Campos, T. Santini, M.A. da Costa Vieira, S. HashemizadehKolowri, E. DiBella, C. Peng, Z. Shen, Z. Chen, I. Ullah, M. Mani, H. Abdolmotalleby, S. Eckstrom, S.H. Baete, P. Filipiak, T. Dong, Q. Fan, R. de Luis-García, A. Tristán-Vega, T. Pieciak. Validation of Deep Learning techniques for quality augmentation in diffusion MRI for clinical studies. NeuroImage: Clinical, 2023
  7. Madison Lewis, Tales Santini, Nicholas Theis, Brendan Muldoon, Katherine Dash, Matcheri Keshavan, Konasale Prasad. Modular architecture and resilience of structural covariance networks in first-episode antipsychotic-naive psychoses. Scientific Reports. 2023
  8. Gabriel Varela-Mattatall, Paul I. Dubovan, Tales Santini, Kyle M. Gilbert, Ravi S. Menon, Corey A. Baron High-resolution single-shot spiral diffusion-weighted imaging at 7T using expanded encoding with compressed sensing. MRM 2023
  9. Nico J. J. Arezza, Tales Santini, Mohammad Omer, Corey A. Baron. Estimation of free water-corrected microscopic fractional anisotropy. Front. Neurosci. 2023
  10. Nicola De Zanche et al. ISMRM Best Practices for Safety Testing of Experimental RF Hardware, 2022.
  11. Mark Whiting, Joseph Mettenburg, Enrico Novelli, Tales Santini, Tiago Martins, Tamer S. Ibrahim, Philip LeDuc, Jonathan Cagan. Inducing Vascular Grammars for Anomaly Classification in Brain Angiograms. Journal of Engineering and Science in Medical Diagnostics and Therapy, 2022.
  12. Tales Santini*, Ashika Mani*, Radhika Puppala*, Megan Dahl, Shruthi Venkatesh, Elizabeth Walker, Megan DeHaven, Cigdem Isitan, Tamer S. Ibrahim, Long Wang, Tao Zhang, Enhao Gong, Jessica Barrios-Martinez, Fang-Cheng Yeh, Robert Krafty, Joseph M. Mettenburg, Zongqi Xia. Applying Deep Learning to Accelerated Clinical Brain Magnetic Resonance Imaging for Multiple Sclerosis. Front. Neurol., 2021. *Equal contribution.
  13. Tales Santini, Sossena Wood, Narayanan Krishnamurthy, Tiago Martins, Howard J. Aizenstein, Tamer S. Ibrahim. Improved 7 Tesla Transmit Field Homogeneity with Reduced Electromagnetic Power Deposition Using Coupled Tic Tac Toe Antennas. Scientific Reports, 2021.
  14. Tales Santini, Minseok Koo, Nadim Farhat, Vinicius P. Campos, Salem Alkhateeb, Marcelo A. C. Vieira, Meryl A. Butters, Caterina Rosano, Howard J. Aizenstein, Joseph Mettenburg, Enrico M. Novelli, Tamer S. Ibrahim. Analysis of Hippocampal Subfields in Sickle Cell Disease Using Ultrahigh Field MRI. Neuroimage: Clinical 2021.
  15. Sossena Wood, Tales Santini, Narayanan Krishnamurthy, Tiago Martins, Nadim Farhat, Tamer S. Ibrahim. A Comprehensive Electromagnetic Evaluation of an MRI Anthropomorphic Head Phantom. NMR in Biomedicine 2020.
  16. Nadim S. Farhat, Robert Theiss, Tales Santini, Tamer S. Ibrahim, Howard J. Aizenstein. Recent advances in Neuroimaging of Small Vessel Disease in Late-life Depression. Advances in Experimental Medicine and Biology (AEMB), book series of Springer, 2019.
  17. Stephen F. Smagula, Sarah T. Stahl, Tales Santini, Layla Banihashemi, Martica H. Hall, Tamer S. Ibrahim, Charles F. Reynolds III, Robert T. Krafty, Howard J. Aizenstein, Liang Zhan. White matter integrity underlying depression symptoms in dementia caregivers. American Journal of Geriatric Psychiatry, 2019.
  18. Tales Santini*, Narayanan Krishnamurthy*, Junghwan Kim, Sossena Wood, Howard Aizenstein, and Tamer S. Ibrahim. Computational and Experimental Evaluations of transmission line Based RF Coils at 7T. PLoS One 2019. *Equal contribution.
  19. Melania Borges, Marcelo Prado, Tales Santini, Adriano Barbosa, Antonio Moreira, Issao Ishibe, Marcelo Katz, Fatima Cintra. Development and clinical validation of a non-invasive, beat-to-beat blood pressure monitoring device, compared to invasive blood pressure monitoring during coronary angiography. Einstein Journal 2019.
  20. Tales Santini, Yujuan Zhao, Sossena Wood, Narayanan Krishnamurthy, Junghwan Kim, Nadim Farhat, Tiago Martins, Tiejun Zhao, Howard Aizenstein, and Tamer S. Ibrahim. In-vivo and numerical analysis of the eigenmodes produced by a multi-level head transmit array for 7 Tesla MRI. PLoS One 2018.
  21. Tales Santini, Junghwan Kim, Sossena Wood, Narayanan Krishnamurthy, Nadim Farhat, Carlos Maciel, Shailesh Raval, and Tamer Ibrahim. A new RF Transmit Coil for Foot and Ankle Imaging at 7T MRI. Magnetic Resonance Imaging 2018.
  22. Stephen F. Smagula, Helmet T. Karim, Anusha Rangarajan, Fernando Pasquini Santos, Sossena C. Wood, Tales Santini, John M. Jakicic, Charles F. Reynolds, Judy L. Cameron, Abbe N. Vallejo, Meryl A. Butters, Caterina Rosano, Tamer S. Ibrahim, Kirk I Erickson, and Howard J. Aizenstein. Association of hippocampal substructure resting-state functional connectivity with memory performance in older adults. American Journal of Geriatric Psychiatry 2018.
  23. Junghwan Kim, Tales Santini, Kyongtae Ty Bae, Narayan Krishnamurthy, Yujuan Zhao, Tiejun Zhao, and Tamer S. Ibrahim. Development of a 7 T RF coil system for breast imaging. NMR in Biomedicine 2017.
  24. Sossena Wood, Narayanan Krishnamurthy, Tales Santini, Shailesh Raval, Nadim Farhat, John Andy Holmes, and Tamer S. Ibrahim. Design and fabrication of a realistic anthropomorphic heterogeneous head phantom for MR purposes. PLoS One 2017.
  25. Shailesh B. Raval, Cynthia A. Britton, Tiejun Zhao, Narayanan Krishnamurthy, Tales Santini, Vijay S. Gorantla, Tamer S. Ibrahim. Ultra-high field upper extremity peripheral nerve and non-contrast enhanced vascular imaging. PLoS One 2017.
  26. Tales Santini, Tamer Ibrahim, and Carlos Maciel. Load-insensitive active quasi-circulator for continuous-wave Doppler ultrasound applications. Electronics Letters 2016.
  27. Junghwan Kim, Narayan Krishnamurthy, Tales Santini, Yujuan Zhao, Tiejun Zhao, Kyongtae Ty Bae, and Tamer S. Ibrahim. Experimental and numerical analysis of B1+ field and SAR with a new transmit array design for 7T breast MRI. Journal of Magnetic Resonance 2016.
  28. Shailesh B. Raval, Tiejun Zhao, Narayanan Krishnamurthy, Tales Santini, Cynthia Britton, Vijay S. Gorantla, Tamer S. Ibrahim. Ultra-high-field RF coil development for evaluating upper extremity imaging applications. NMR Biomed 2016
  29. Miguel Filho, Alexandre R. Marra, Thyago Magnus, Rodrigo Rodrigues, Marcelo Prado, Tales Santini, Elivane Victor, Eder Ishibe, Oscar Santos, Michael Edmond. Comparison of human and electronic observation for the measurement of compliance with hand hygiene. American Journal of Infection Control 2014.

Projects

    MAJOR PROJECTS:

    Electromagnetic simulations and implementation of innovative RF coil designs for 7T MRI:

    • Foot/ankle transmit RF coil
    • 16-channel transmit head RF coil
    • 16-channel transmit body RF coil
    • 56-channel transmit head RF coil

    Optimization of multi-channel RF coils (RF shimming):

    • 16-channel head coil
    • 56-channel head coil

    High-resolution image acquisition at 7T MRI:

    • Foot/ankle RF coil
    • 16-channel head coil

    Post-processing of in-vivo human MRI data:

    • Functional MRI (task-based)
    • Diffusion MRI and fiber tracking
    • Image denoising
    • Hippocampus subfields and brain segmentation

    Development of electronic medical devices

    • Hand hygiene monitor for hospital environment
    • Multiparameter device
    • Tonometer for beat-to-beat non-invasive blood pressure measurement and tilt-table test
    • Pulse oximeter
    • Electrocardiograph

Proceedings

  1. Tales Santini, Jinghang Li, James E Emanuel, Jr-Jiun Liou, Andrea Sajewski, Cong Chu, Bruno de Almeida, Brian J Lopresti, Howard J Aizenstein, Minjie Wu, Ariel Gildengers, Tamer S Ibrahim. Associations of gray matter volume and white mater hyperintensity mean diffusivity and volume with PiB status in mild cognitive impairment. AAIC 2024
  2. Bruno de Almeida, Tiago Amaro Martins, Minjie Wu, Kristine A Wilckens, Davneet S Minhas, James W Ibinson, Howard J Aizenstein, Tales Santini, Tamer S Ibrahim. Characterization of pulsations in the brain and cerebrospinal fluid using ultra-high field magnetic resonance imaging. AAIC 2024
  3. Cong Chu, Tales Santini, Anna Marsland, Peter Gianaros, Tamer S Ibrahim. Brain morphometrics and aging with paired 3T and 7T structural MRI: 7T reduces reqiured sample size and improves statistical significance. AAIC 2024
  4. Jr-Jiun Liou, Jinghang Li, Jacob Berardinelli, Hecheng Jin, Tales Santini, Jaehoon Noh, Nadim Farhat, Howard J Aizenstein, William Yong, Elizabeth Head, Milos D Ikonomovic, Tamer S Ibrahim, Julia Kofler. Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI. AAIC 2024
  5. Jacob Berardinelli, Jinghang Li, Nadim Farhat, Jr-Jiun Liou, Andrea Sajewski, Tales Santini, Minjie Wu , Joseph Mettenburg, Howard J Aizenstein, Milos D Ikonomovic, Julia Kofler, Tamer S Ibrahim. Advancements in High-Resolution MRI Postmortem brain imaging: Histological examination on cells exclusively exhibiting White Matter Hyperintensities made possible using a novel, 3D printed, reusable, imaging container and cutting guide. AAIC 2024
  6. Elizabeth Meinert-Spyker, Tales Santini, Sharadhi Umesh Bharadwaj, Charles Jonassaint, Meryl Butters, Olubusola Oluwole, Enrico Novelli, Tamer Ibrahim, Sossena Wood. Fractional Anisotropy Varies with Age, Cognition, and Depression in Patients with Sickle Cell. OHBM 2024.
  7. Nahom Mossazghi, Nadim Farhat, Tales Santini, Olubusola Oluwole, Enrico Novelli, Tamer Ibrahim, Sossena Wood. Investigating disruptions in information flow due to Sickle Cell Disease using Granger Causality. OHBM 2024
  8. Tales Santini, Salem Alkateeb, Jr-Jiun Liou, Jinghang Li, Oluwatobi F Adeyemi, Gabriel A. de Erausquin, Valentina R. Garbarino, Monica Goss, Mohamad Habes, Jayandra Jung Himali, Christof Karmonik, Karl Li, Joseph C. Masdeu, Rejani R Nair, Vibhuti N Patel, Beth E. Snitz, Richard Bowtell, Gowland Penny, Gustavo C Roman, Mary Ganguli, Farhaan S Vahidy, Timothy D. Girard, Heidi I.L. Jacobs, Akram A. Hosseini, Sudha Seshadri, Tamer Ibrahim. Hippocampal subfield volumes in COVID-19: a preliminary multicenter study using 7T MRI. AAIC 2023 (oral presentation)
  9. Tamer Ibrahim, Tales Santini, Nadim Farhat, Salem Alkateeb, Andrea Sajewski, Eduardo Diniz, Jacob Berardinelli, Jinghang Li, Hecheng Jin, Robin Chu, Jr-Jiun Liou, Bruno de Almeida, Anthony DeFranco, William Salmon, Jeremy Berardo. 7 Tesla Brain MRI: A Paradigm Shifting Technology for Clinical Research in Aging and Dementia Science. AAIC 2023 (oral presentation)
  10. Jinghang Li, Jr-Jiun Liou, Tales Santini, Salem Alkateeb, Oluwatobi F Adeyemi, Gabriel A. de Erausquin, Valentina R. Garbarino, Monica Goss, Mohamad Habes, Jayandra Jung Himali, Christof Karmonik, Karl Li, Joseph C. Masdeu, Rejani R Nair, Vibhuti N Patel, Beth E. Snitz, Howard J Aizenstein, Minjie Wu, Richard Bowtell, Gowland Penny, Gustavo C Roman, Mary Ganguli, Farhaan S Vahidy, Timothy D. Girard, Heidi I.L. Jacobs, Akram A. Hosseini, Sudha Seshadri, Tamer Ibrahim. Investigating white matter hyperintensities in a multicenter COVID-19 study using 7T MRI. AAIC 2023 (oral presentation)
  11. Akram A. Hosseini, Oluwatobi F Adeyemi, Richard Bowtell, Gowland Penny, Tamer Ibrahim, Jr-Jiun Liou, Tales Santini, Jinghang Li, Salem Alkateeb, Mohamad Habes, Monica Goss, Farhaan S Vahidy, Heidi I.L. Jacobs, Timothy D. Girard, Gabriel A. de Erausquin, Heather M Snyder, Sudha Seshadri. Using 7T MRI to study hippocampal structures in Alzheimer’s disease and post-SARS-CoV2 infection. AAIC 2023 (oral presentation)
  12. Sharadhi Umesh Bharadwaj, Tales Santini, Enrico Novelli, Busola Oluwole, Tamer S. Ibrahim, Sossena Wood. Investigating accelerated brain aging in Sickle Cell Disease. OHBM 2023
  13. Elizabeth Meinert-Spyker, Tales Santini, Sharadhi Umesh Bharadwaj, Enrico Novelli, Tamer S. Ibrahim, Sossena Wood. Sickle cell disease (SCD) subtype and sex analysis of diffusion metrics on 7T MRI. OHBM 2023
  14. Tales Santini, Naila Rahman, Alyson Shim, Matthew Budde, Stefan Everling, and Corey Baron. Evidence of axon beading and loss of extracellular fluid following perfusion and fixation of the marmoset brain. ISMRM 2023
  15. Vinicius P. Campos, Tales Santini, Corey Baron, and Marcelo A. C. Vieira. Exploiting diffusion MRI data redundancy on a denoising framework - application on MR images (OGSE, μFA protocols) of the Marmoset Brain (in-vivo). ISMRM 2023
  16. Sharadhi Umesh Bharadwaj, Tales Santini, Joel D.K Disu, Busola Oluwole, Enrico M. Novelli, Tamer S Ibrahim, and Sossena Wood. Analyzing Cortical Thickness and Volume in patients with Sickle Cell Disease using 7T-MRI. ISMRM 2023
  17. Hecheng Jin, Andrea N Sajewski, Tales Santini, Tiago Martins, Jacob P Berardinelli, Anthony DeFranco, Howard J Aizenstein, and Tamer S Ibrahim. Investigating the impact of head position on the spatial distribution of B1+ field for a 60-ch Txcoil at 7T. ISMRM 2023
  18. Jacob Patrick Berardinelli, Julia Kofler, Jinghang Li, Owen Flaugh, Nadim Farhat, Tales Santini, Andrea Sajewski, Noah Schweitzer, Joseph Mettenburg, Milos Ikonomovic, Howard J. Aizenstein, and Tamer S.Ibrahim. Postmortem Imaging with Reusable 3D Printed Ex Vivo Brain Enclosures/Cutting Guide for MRIRegistration with Gross Anatomy Photographs at 7T. ISMRM 2023
  19. Elizabeth Meinert-Spyker, Tales Santini, Sharadhi Umesh Bharadwaj, Enrico Novelli, Tamer Ibrahim, and Sossena Wood. Patients with sickle cell disease have altered brain fractional anisotropy, axial, mean and radial diffusivity quantified by 7T MRI. ISMRM 2023
  20. Andrea N Sajewski, Tales Santini, Tiago Martins, Jacob Berardinelli, and Tamer Ibrahim. Comparison of the Optimization of a 60-channel Transmit Coil in pTx and sTx mode at 7T. ISMRM 2023.
  21. Andrea N Sajewski, Tales Santini, Anthony DeFranco, Boris Keil, Hecheng Jin, Jacob Berardinelli, Jinghang Li, Cong Chu, Tiago Martins, and Tamer S Ibrahim. An Open 60-channel Tx/ 32-channel Rx RF Coil System for Routine Use at 7T. ISMRM 2023. Oral presentation.
  22. Paul I. Dubovan, Gabriel Varela-Mattatall, Tales Santini, Kyle M. Gilbert, Ravi S. Menon, and Corey A. Baron. High-resolution single-shot spiral diffusion-weighted imaging at 7T using the expanded encoding model and compressed sensing. ISMRM 2023.
  23. Santiago Aja-Fernandez et al. Validation of Deep Learning techniques for quality augmentation in diffusion MRI for clinical studies. ISMRM 2023.
  24. Renata M. Maria, Vinícius P. Campos, Tales Santini, Rodrigo Vimieiro, Marcelo A. C. Vieira Video frame interpolation network to generatecdiffusion weighted images. QUAD22 Challenge, Miccai 2022
  25. Tales Santini, Naila Rahman, Alyson Shim, Matthew D. Budde, Wataru Inoue, Stefan Everling, and Corey Baron. Investigating microstructure changes between in vivo and ex vivo marmoset brains using advanced diffusion MRI at 9.4T and Monte Carlo simulations. ISMRM diffusion workshop, Amsterdam, Netherlands 2022
  26. Gabriel Varela-Mattatall, Paul I. Dubovan, Tales Santini, Kyle M. Gilbert, Ravi S. Menon, Corey A. Baron. High-resolution single-shot spiral diffusion-weighted imaging at 7T using the expanded encoding model and compressed sensing. 13th symposium on ultrahigh field MR. Berlin, Germany 2022
  27. Tales Santini, Naila Rahman, Alyson Shim, Wataru Inoue, Stefan Everling, and Corey Baron. Oscillating Gradient (OGSE) and Microscopic Anisotropy Diffusion in the in vivo and ex vivo Marmoset Brain. ISMRM, 2022, oral presentation.
  28. Tales Santini, Naila Rahman, Alyson Shim, Wataru Inoue, Stefan Everling, Corey Baron. Investigating microstructure changes between in-vivo and ex-vivo marmoset brains using advanced diffusion MRI at 9.4T. Robarts Retreat, London ON. 2022.
  29. Gabriel Varela-Mattatall, Paul Dubovan, Tales Santini, Kyle Gilbert, Ravi S. Menon, Corey A. Baron. Higher-order reconstruction with compressed sensing regularization. Robarts Retreat, London ON. 2022.
  30. Salem Alkhateeb, Tales Santini, Li jinghang, Robin Chu, Daniel Ibrahim, Anna M. Marsland, Stephen B. Manuck, Pete Gianaros, and Tamer S. Ibrahim. Hippocampal Subfields Volume in Middle Age Healthy Adults. ISMRM, 2022
  31. Nadim Farhat, Heching Jin, Tales Santini, Tiago Martins, Jacob Berardinelli, Noah Schweitzer, Salem AlKhateeb, Milos Ikonomovic, Julia Ann Kofler, Joseph Mettenburg, Howard J. Aizenstein, and Tamer S.Ibrahim. Addressing ultra highfield MRI challenges in ex-vivo. ISMRM, 2022
  32. Jacob P. Berardinelli, Julia Kofler, Noah Schweitzer, Nadim Farhat, Tales Santini, Andrea Sajewski, Joseph Mettenburg, Milos Ikonomovic, Howard J. Aizenstein, and Tamer S. Ibrahim. Reusable 3D Printed Ex-vivo Brain Enclosure and Two-Piece Cutting Guide for Axial and CoronalMRI Registration with Gross Anatomy Photographs. ISMRM, 2022
  33. Andrea N Sajewski, Tales Santini, Anthony DeFranco, Tiago Martins, Jacob Berardinelli, Howard J Aizenstein, and Tamer S Ibrahim. Impact of Coupling on the B1+ Field Produced by a 15-panel Tic-Tac-Toe RF Array. ISMRM, 2022
  34. Nadim Farhat, Helmet Karim, Tales Santini, Leticia Candra, Caterina Rosano, Howard Aizenstein, Enrico Novelli, Tamer Ibrahim. Characterization of Resting-State Default Mode Network in Individuals with HbSS and HbSC, and Healthy Controls Using 7-Tesla Human MRI. ASH Annual Meeting 2021, https://doi.org/10.1182/blood-2021-153558
  35. Olubusola Oluwole, Tales Santini, Joseph Mettenburg, Enrico M Novelli, Tames S. Ibrahim. Cortical Thinning and White Matter Loss in Sickle Cell Anemia Despite Chronic Exchange Transfusion Therapy. ASH Annual Meeting 2021, https://doi.org/10.1182/blood-2021-144460
  36. Bridget McGuigan, Tales Santini, Konasale M. Prasad. Cortical Thickness Influenced by Gene Expression in Schizophrenia Patients: A Study Utilizing the HCP Atlas. Pitt Psychiatry Research day, 2021
  37. Tales Santini, Minseok Koo, Nadim Farhat, Vinicius P. Campos, Salem Alkhateeb, Marcelo A. C. Vieira, Meryl A. Butters, Caterina Rosano, Howard J. Aizenstein, Joseph Mettenburg, Enrico M. Novelli, Tamer S. Ibrahim. Patients With Sickle Cell Disease Have Reduced Volumes of Hippocampal Subfields: A 7 Tesla MRI Study. 19th Annual Department of Medicine Research Day, Pittsburgh 2021 (oral presentation)
  38. Tales Santini, Anthony DeFranco, Tiago Martins, Andrea Sajewski, Howard J. Aizenstein, and Tamer S. Ibrahim. A 28-channel decoupled Tic-Tac-Toe transmit radiofrequency coil for 7T MRI. ISMRM 2021
  39. Tales Santini, Minseok Koo, Nadim Farhat, Vinicius P. Campos, Salem Alkhateeb, Marcelo A. C. Vieira, Meryl A. Butters, Caterina Rosano, Howard J. Aizenstein, Joseph Mettenburg, Enrico M. Novelli, Tamer S. Ibrahim. Hippocampal segmentation from 7T images showed reduced subfields volume in Sickle Cell Disease subjects. ISMRM 2021
  40. Tiago Martins, Tales Santini, Jacob Berardinelli, Anthony DeFranco, and Tamer S Ibrahim. Conformal design of radio-frequency head coil for ultra-high field MRI. ISMRM 2021
  41. Salem Alkhateeb, Tales Santini, Tiago Martins, nadim farhat, and Tamer S. Ibrahim. A separate RF Neck Coil for Arterial Spin Labeling at 7T MRI. ISMRM 2021
  42. Andrea N Sajewski, Tales Santini, Matthew Saich, Tiago Martins, and Tamer S Ibrahim. Development of a Microstrip Tx Coil Module for 7T MRI. ISMRM 2021
  43. Tiago Martins, Tales Santini, Minjie Wu, Kristine Wilckens, Davneet Minhas, James W. Ibinson, Howard J. Aizenstein, and Tamer S. Ibrahim. Characterization of cerebrospinal fluid using ultra-high field MRI. ISMRM 2021
  44. Salem Alkhateeb, Tales Santini, Regina Leckie, Nadim Farhat, Peter J Gianaros, Anna L Marsland, Stephen B Manuck, and Tamer S Ibrahim. The Volume of Hippocampal Subfields in correlation with Middle Age Healthy Adults. ISMRM 2021
  45. Eduardo Diniz, Karim Helmet, Tales Santini, Howard Eizenstein, and Tamer Ibrahim. Image-to-image translation of 3T to 7T MRI using Generative Adversarial Networks: A steptowards longitudinal harmonization. ISMRM 2021
  46. Nadim Farhat, Julia Kofler, Jacob Berardinelli, Mark Stauffer, Tales Santini, Neilesh Vinjamuri, Andrea Sajewski, Salem Alkhateeb, Tiago Martins, Noah Schweitzer, Milos Ikonomovic, Howard J.Aizenstein, and Tamer S Ibrahim. Reusable 3D printed enclosure with integrated cutting guides for the alignment of ex-vivo MRIwith ex-vivo gross brain photographs. ISMRM 2021
  47. Brendan Muldoon, Nicholas Theis, Tamer Ibrahim, Tales Santini, Matcheri Keshavan, Satish Iyengar, Shaun Eack, Vishwajit Nimgaonkar, Konasale Prasad. Altered Trisynaptic Hippocampal Network Regions in Psychosis Risk States: An Integrated Hippocampal Shape and Subregion Study Using Ultra-High Field MRI Data. Biological Psychiatry 2020, https://doi.org/10.1016/j.biopsych.2020.02.926
  48. Alexander Saunders, Tales Santini, Tiago Martins, Howard Aizenstein, John C. Wood, Matthew Borzage, Tamer S. Ibrahim. Performance of Automatic Cerebral Arterial Segmentation of MRA Images Improves at Ultra-high Field. ISMRM 2020.
  49. Stephen Smagula, Tales Santini, Sarah Stahl, Tamer Ibrahim, Charles Reynolds, Richard Schulz, Layla Banihashemi, Liang Zhan. White Matter Integrity Underlying Subsyndromal Depression Symptoms in Dementia Caregivers. Gerontological Society of America annual meeting, Austin, TX, 2019, https://doi.org/10.1016/j.jagp.2019.11.010
  50. Matthew Saich, Tales Santini, Neilesh Vinjamuri, Tiago Martins, Zachary Fritts, Minseok Koo, Salem Alkhateeb, Nadim Farhat, Tamer S. Ibrahim. Construction and Testing of the 4-channel Microstrip Tic-Tac-Toe RF coil Design for 7T MRI. BMES 2019
  51. Danesh Thirukumaran, Tales Santini, Sossena Wood, Nadim Farhat, Salem Alkhateeb, Tiago Martins, Howard Aizenstein, Enrico Novelli, Tamer S. Ibrahim. Utilization of DTI analysis for Sickle Cell Disease related Cerebral Infarction. BMES 2019
  52. Tales Santini, Sossena Wood, Howard J. Aizenstein, Tamer S. Ibrahim. Homogenous 64-channel RF transmit array for brain imaging at 7T, 9.4T, and 10.5T. ISMRM 2019
  53. Tales Santini, Sossena Wood, Narayanan Krishnamurthy, Tiago Martins, Nadim Farhat, Salem Alkhateeb, Howard J. Aizenstein, Tamer S. Ibrahim. Optimization of RF system for homogenous, consistent, and safe neuro imaging at 7T MRI. ISMRM 2019
  54. Nadim Farhat, Helmet Karim, Tales Santini, Neilesh Vinjamuri, Howard Aizenstein, Enrico M Novelli, Tamer Ibrahim. Default mode networks connectivity characterization in young adults with sickle cell disease using 7T resting functional magnetic resonance imaging. ISMRM 2019
  55. Tales Santini, Fabricio Brito, Sossena Wood, Tiago Martins, Joseph Mettenburgh, Howard Aizenstein, Marcelo Vieira, Tamer S. Ibrahim. Noise mitigation of high-resolution 7T MRI images. In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France, 2018.
  56. Tales Santini, Sossena Wood, Narayanan Krishnamurthy, Yutong Zhang, Howard Aizenstein, Tamer S. Ibrahim. New optimization strategies for RF shimming at UHF MRI. In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France, 2018.
  57. Tales Santini, Yujuan Zhao, Sossena Wood, Junghwan Kim, Nadim Farhat, Narayanan Krishnamurthy, Tiejun Zhao, Tamer S. Ibrahim. Experimental and Numerical Evaluations of Simultaneously Excited Eigenmodes in a 20-channel Transmit RF Array for 7 Tesla human MRI. In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France, 2018.
  58. Sossena Wood, Tales Santini, Nadim Farhat, Tiago Martins, Narayanan Krishnamurthy, Tamer S. Ibrahim. B1+ and Temperature Analysis in Two UHF RF Coils. In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France, 2018.
  59. Sossena Wood, Tales Santini, Narayanan Krishnamurthy, Tiago Martins, Tamer S. Ibrahim. Comparison of Electric and B1+ Fields for Heterogeneous and Homogeneous Anthropomorphic Phantoms and Anatomical Models: Numerical Simulations and Experimental Findings. In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France, 2018.
  60. Minseok Koo, Tales Santini, Neilesh Vinjamuri, Sossena Wood, Nadim Farhat, Tiago Martins, Salem Alkhateeb, Tamer S. Ibrahim. Building and Testing of the 64-channel Radio Frequency (RF) Head Coil for Ultra-High Field MRI Applications. BMES 2018
  61. Sossena Wood, Tiago Martins, Tales Santini, Tamer S. Ibrahim. An electrically conductive SLA resin used for the Design of Anthropomorphic Phantoms. In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France, 2018.
  62. Nadim Farhat, Julia Kofler, Tales Santini, Sossena Wood, Tiago Martins, Salem Alkhateeb, Shane McKeon, Anusha Rangarajan, Howard Aizenstein, Tamer S. Ibrahim. Utility of 7T postmortem MRI in investigating Alzheimer's disease. Aging institute day, University of Pittsburgh, 2018.
  63. Shane McKeon, Anusha Rangarajan, Minjie Wu, Nadim Farhat, Tales Santini, Sossena Wood, Tamer Ibrahim, Milos Ikonomovic, Julia Kofler, Oscar Lopez, Bill Klunk, Howard Aizenstein. Co-registration of MRI-defined White Matter Lesions with Ex-Vivo Histopathology. BMES 2018.
  64. S. Mckeon, A. Rangarajan, M. Wu, N. Farhat, T. Santini, S. Wood, T. Ibrahim, M. Ikonomovic, J. Kofler, O. Lopez, B. Klunk, H.Aizenstein. Co-registration of mri-defined white matter lesions with ex-vivo registration. SfN
  65. Tales Santini, Junghwan Kim, Sossena Wood, Narayanan Krishnamurthy, Shailesh Raval, Tamer Ibrahim. A new RF coil for foot and ankle imaging at 7T MRI. In Proc. of the 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, Hawaii, April 2017.
  66. Tales Santini, Narayanan Krishnamurthy, Sossena Wood, Shailesh Raval, Yujuan Zhao, Anthony Fischetti, Minseok Koo, Howard Aizenstein, Tamer Ibrahim. 64-channel Double-Octagon Tx Head Coil for 7T Imaging. In Proc. of the 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, Hawaii, April 2017.
  67. Tamer Ibrahim, Tales Santini, Shailesh Raval, Narayanan Krishnamurthy, Sossena Wood, Junghwan Kim, Yujuan Zhao, Xiaoping Wu, Essa Yacoub, Howard Aizenstein, and Tiejun Zhao. Towards Homogenous 7T Neuro Imaging: Findings and Comparisons between 7T TTT and NOVA RF Coil Systems. In Proc. of the 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, Hawaii, April 2017.
  68. Shailesh Raval, Tales Santini, Sossena Wood, Narayanan Krishnamurthy, and Tamer Ibrahim. In-vivo (8x4) 32-ch Tx-only Body Array for UHF MRI. In Proc. of the 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, Hawaii, April 2017.
  69. Neilesh Vinjamuri, Tales Santini, Sossena Wood, Tamer S. Ibrahim. Optimizing geometry of a 64-channel RF head coil. BMES 2017
  70. Sossena Wood, Narayanan Krishnamurthy, Tales Santini, Shailesh Raval, and Tamer Ibrahim. Evaluation of an Anthropomorphic Phantom with In-Vivo Using Quantitative MRI. In Proc. of the 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, Hawaii, April 2017.
  71. Shane McKeon, Anusha Rangarajan, Minjie Wu, Tales Santini, Tamer S Ibrahim, Oscar Lopez, Howard Aizenstein. Evaluation of Segmentation Performance with 3T and 7T Magnetic Resonance Imaging using FreeSurfer. BMES 2017
  72. Shane McKeon, Naomi Joseph, Anusha Rangarajan, Minjie Wu, Nadim Farhat, Tales Santini, Sossena Wood, Tamer Ibrahim, Milos Ikonomovic, Julia Kofler, Oscar Lopez, Bill Klunk, Howard Aizenstein. Co-Registration of In-Vivo and Ex-Vivo Human MRI Brain Images. Science 2017
  73. Fernando P. Santos, Stephen F. Smagula, Helmet Karim, Tales Santini, Howard J. Aizenstein, Tamer S. Ibrahim, and Carlos D. Maciel. Dynamic Bayesian Network Modeling of Hippocampal Subfields Connectivity with 7T fMRI: A Case Study. Biosignals, 2016.
  74. Narayanan Krishnamurthy, Yujuan Zhao, Shailesh Raval, Junghwan Kim, Sossena Wood, Tales Santini, Tiejun Zhao, and Tamer S. Ibrahim. 7T Multi-slab Whole-Head Homogenous and Low SAR T2 Acquisitions with Limited RF Power Amplifiers Capabilities. International Society for Magnetic Resonance in Medicine, 2015.
  75. Shailesh Raval, Tiejun Zhao, Narayanan Krishnamurthy, Tales Santini, Vijay S. Gorantla, and Tamer S. Ibrahim. Upper extremity neural and vascular imaging with UHF 7T MRI. International Society for Magnetic Resonance in Medicine, 2015.

Patents

  1. Marra, et al. "System and a method for monitoring hand sanitizing opportunities in hospital wards." US 9679464 B2, 2017. Available at https://patents.google.com/patent/US9679464
  2. Marra, et al. "System and method of monitoring physical contact events in a hospital environment", US 10074264 B2, 2018. Available at https://patents.google.com/patent/US20180144609A1
  3. Marra, et al. "System and method of monitoring patients in hospital beds", application number US 20180049677 A1. Submitted in 2017. Available at https://patents.google.com/patent/US20180049677A1
  4. Prado, et al. "Portable device for the analysis of skin traumas and method for analyzing skin traumas using a portable device" Available at https://patents.google.com/patent/US20180042487A1
  5. Marra, et al. "System and method for detecting the physical contact events in a hospital environment, and use of the human body as a means for transmitting an identification signal in a system for detecting the physical contact events in a hospital environment" Available at https://patents.google.com/patent/US10629301B2/en

News

"Using Advanced Imaging to Study Sickle Cell Disease" described the recent findings in Sickle Cell Disease using the technology developed at the University of Pittsburgh

"Impacting human life now" is an article describing the projects conducted at the University of Pittsburgh

First place in the Eric Roger Wroclawski Award 2019 with the paper "Development and clinical validation of a non-invasive, beat-to-beat blood pressure monitoring device, compared to invasive blood pressure monitoring during coronary angiography"

In the new for the work lead by Dr. Sossena Wood in "Design and fabrication of a realistic anthropomorphic heterogeneous head phantom for MR purposes"

Participations in the best practices for safety testing of experimental RF hardware, a working group supported by the International Society of Magnetic Resonance in Medicine (ISMRM).

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